The Centers for Disease Control and Prevention (CDC) Climate and Health program released a framework to help health departments anticipate and assess the health effects of climate change impacts. This report, Assessing Health Vulnerability to Climate Change, is the first in a five-part series done under the auspices of the CDC Building Resilience Against Climate Effects (BRACE) framework. The report describes five actions health departments can take to address climate change-exacerbated health vulnerabilities and provides a case study using data from Georgia to assess vulnerability to extreme heat.